This metabolite incorporates a PDE selectivity profile much like sildenafil and an in vitro potency for PDE5 about 50% of your parent drug. Plasma concentrations of this metabolite are somewhere around forty% of These witnessed for sildenafil, so which the metabolite accounts for approximately twenty% of sildenafil's pharmacologic effects.
VIAGRA includes sildenafil, which is identical drugs found in Yet another drug named REVATIO. REVATIO is applied to treat a exceptional illness named pulmonary arterial hypertension (PAH).
Pulmonary arterial hypertension, a condition where you have high blood pressure during the blood vessels that carry blood from your coronary heart to your lungs
There was no effect on sperm motility or morphology following single a hundred mg oral doses of VIAGRA in healthful volunteers.
Wellbeing disorders or components that elevate the potential risk of optic nerve difficulties, for example diabetic issues, substantial cholesterol, smoking, getting older than 50, or possessing a “crowded disc,” which is something an eye physician might even see in an eye Test
The suggest profiles in the adjust from baseline in standing systolic blood pressure level in topics dealt with with doxazosin in combination with 25 mg VIAGRA or matching placebo are shown in Determine two.
Convey to your doctor if you are pregnant or system to become pregnant throughout cure with Viagra. It really is unknown if Viagra passes into breast milk or if it could damage a nursing newborn. Speak to your physician in advance of breastfeeding.
Examination of the security database from controlled scientific trials showed no obvious change in adverse reactions in patients having VIAGRA with and with no anti-hypertensive medication.
Several of such functions were described to happen all through or shortly soon after sexual exercise, and a few had been described to occur shortly soon after the usage of VIAGRA without the need of sexual exercise. Other people were reported to get transpired hrs to times following the use of VIAGRA and sexual activity. It really is not possible to find out no matter whether these functions are associated directly to VIAGRA, to sexual exercise, to your affected person's underlying heart problems, to a combination of these components, or to other things [see WARNINGS AND PRECAUTIONS and PATIENT Information and facts].
Sexual action can place an extra pressure on your coronary heart, particularly when your coronary heart is by now weak from the heart assault or heart problems. Talk to your doctor if your coronary heart is healthful adequate to handle the additional pressure of having sexual intercourse.
Legemidlet skal ikke tas sammen med grapefrukt eller grapefruktjuice da dette kan gi angina og hjerteinfarkt. Medisinen skal heller ikke tas samtidig som andre orale eller lokale behandlinger mot erektil dysfunksjon.
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Sildenafil is a strong and selective inhibitor of cGMP-precise phosphodiesterase style 5 (PDE5), which can be liable for degradation of cGMP in the corpus cavernosum. The molecular construction of sildenafil is comparable to that of cGMP and functions to be a aggressive binding agent of PDE5 in the corpus cavernosum, resulting in additional cGMP and amplified penile reaction to read more sexual stimulation.
Viagra experienced no effect on saquinavir pharmacokinetics. A more robust CYP3A4 inhibitor such as ketoconazole or itraconazole may very well be expected to own bigger impact than that witnessed with saquinavir. Inhabitants pharmacokinetic information from sufferers in medical trials also indicated a discount in sildenafil clearance when it was co-administered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].